TY - JOUR
T1 - Nanoparticle-based drug delivery system for Oral Cancer
T2 - Mechanism, challenges, and therapeutic potential
AU - Hasan, Nurhasni
AU - Aftab, Maryam
AU - Ullah, Muneeb
AU - Nguyen, Phuong Tram
AU - Agustina, Rina
AU - Djabir, Yulia Yusrini
AU - Tockary, Theofilus A.
AU - Uchida, Satoshi
N1 - Publisher Copyright:
© 2025
PY - 2025/3
Y1 - 2025/3
N2 - Oral cancer represents a major global health concern, characterized by high mortality rates attributed to late diagnosis and the constraints of traditional treatment methods. Chemotherapeutic, and radiotherapeutic methods frequently lead to significant side effects, elevated recurrence rates, and inadequate targeting. Recent advancements in nanotechnology provide innovative, targeted therapeutic strategies that enhance bioavailability and decrease toxicity. This review provides an overview of nanoparticle applications in oral cancer therapy, outlining mechanisms, advantages, limitations, and potential clinical impacts. Nanoparticles, encompassing organic, inorganic, and hybrid types (combined organic and inorganic materials), are investigated for their distinct properties in targeted drug delivery, with the objective of addressing existing therapeutic challenges. Despite encouraging preclinical results, issues related to nanoparticle stability, safety, and regulatory considerations remain, necessitating additional research to connect experimental outcomes with clinical applications.
AB - Oral cancer represents a major global health concern, characterized by high mortality rates attributed to late diagnosis and the constraints of traditional treatment methods. Chemotherapeutic, and radiotherapeutic methods frequently lead to significant side effects, elevated recurrence rates, and inadequate targeting. Recent advancements in nanotechnology provide innovative, targeted therapeutic strategies that enhance bioavailability and decrease toxicity. This review provides an overview of nanoparticle applications in oral cancer therapy, outlining mechanisms, advantages, limitations, and potential clinical impacts. Nanoparticles, encompassing organic, inorganic, and hybrid types (combined organic and inorganic materials), are investigated for their distinct properties in targeted drug delivery, with the objective of addressing existing therapeutic challenges. Despite encouraging preclinical results, issues related to nanoparticle stability, safety, and regulatory considerations remain, necessitating additional research to connect experimental outcomes with clinical applications.
KW - Bioavailability
KW - Drug delivery
KW - Nanoparticles
KW - Oral cancer
KW - Targeted therapy
UR - https://www.scopus.com/pages/publications/85216793176
U2 - 10.1016/j.rechem.2025.102068
DO - 10.1016/j.rechem.2025.102068
M3 - Review article
AN - SCOPUS:85216793176
SN - 2211-7156
VL - 14
JO - Results in Chemistry
JF - Results in Chemistry
M1 - 102068
ER -
