In situ gel forming formulations for topical drug delivery

The “In situ gel” is a promising drug delivery system characterized by the ability to shift from a liquid to a gel when applied. These gelation mechanisms are induced by environmental factors such as changes in pH, temperature, ion concentrations, or specific pH. This chapter explores the classification of in situ gel based on stimuli and offers an overview of topical drug administration routes using in situ gel systems, including transdermal, ocular, nasal, vaginal, and rectal applications. In addition, this chapter also presents the recent research and innovative formulations in the development of in situ gel for topical drug delivery that is crucial for enhancing efficiency and patient compliance. This comprehensive investigation provides a profound understanding of the potential of in situ gel, and it is expected to stimulate continued innovation in the field of in situ gel to address issues in topical drug delivery.