Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis

Aim: This study aims to examine the comparative risk of obesity in the FTO rs9939609 genotype in multiethnic groups in Asia, considering that obesity has become a global disease. Data synthesis: Data searches were carried out in several electronic databases: PubMed, Scopus, Google Scholar, ScienceDirect, ClinicalTrials.gov and NCBI. The search involved a combination of keywords related to genetics and obesity risk. Pooled Odds Ratio (POR) with 95% CI was calculated based on the pooled data. Review Manager (RevMan) 5.4.1 were used to analyze the data. Results: From 18 studies, the results of the dominant genetic model AA vs. TT showed POR 95%Cl = 1.95 (1.36–2.80); p < 0.00001, in AA vs. TA genetic recessive model, POR 95%Cl =1.31 (1.07–1.60); p = 0.002, then the final model of TA vs. TT codominance genetic model obtained POR 95%Cl = 1.52 (1.04–2.23); p < 0.00001. The overall risk of bias was low. Conclusion: From this research, it was found that there was a comparison of the genotype that had a higher risk of obesity, namely the AA genotype in multiethnic groups in Asia. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=546434.